After experimenting on Spine 2D Trial Version, the initial impression would be an overwhelmingly how to do this and where do I start. The learning curve of Spine isn't tool steep relative to learning a new framework or language (software). It greatly address a lot of 2D animation issues, specially the consistency of transition and flow in a skeletal bone structured level. Aside from creating and exporting graphics, the tool is extremely useful in optimizing sprite files sizes but in expense of CPU usage.